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. 2022 Jul 28;23(8):1256–1272. doi: 10.1038/s41590-022-01271-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — (a,b) Clonal expansion with somatic hypermutation, isotype switches and antigen selection in CD38⁻ and CD27⁺ B cell compartments. Lineage network diagrams were generated for CD38⁻ (a), and CD27⁺ B cell (b) compartments as described in Fig. 6a and Methods. One representative HC-Ag is shown from n = 5, and all other sequenced subjects are shown (HC-N, n = 1, pRD-N n = 1 and pRD-Ag n = 5). (c) Clonal sharing between CD38^int, CD38⁻ and CD27⁺ repertoires. Clonal relatedness is shown as in Fig. 6c for the all the additional investigated subjects not shown in Fig. 6c. Note that no sufficient amount of CD38⁻ cells was available from either infant donor, however, repertoire analysis was possible from new emigrant transitional cells (NE), therefore, circular visualization plots were generated for the infant subjects on the NE, CD38^int and CD27⁺ compartments.