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. 2022 Jul 14;54(8):1103–1116. doi: 10.1038/s41588-022-01113-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Multi-omics data for genome-wide Hi-C, ATAC-seq, H3K27ac ChIP-seq, and RNA-seq of three bladder cancer cell lines (SRA: PRJNA623018) were analyzed and visualized using UCSC genome browser. OAS1, OAS2, and OAS3 expression was observed in all samples, but there is no evidence of open chromatin, enhancer activity, or chromatin interactions within the region that includes 79 variants associated with hospitalized versus nonhospitalized COVNET COVID-19 in patients of European ancestry (Fig. 1).