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. 2022 Jul 14;54(8):1103–1116. doi: 10.1038/s41588-022-01113-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Analysis of allelic expression imbalance for transcribed OAS1 variants based on RNA-seq reads. b,c, Counts of allele-specific RNA-seq reads in heterozygous samples for transcribed OAS1 variants rs1131454 and rs2660 in nasal epithelial cells uninfected (Mock) and infected with rhinovirus (RV) strains A or C (RVA or RVC) (b) or in PBMCs from patients with COVID-19 and healthy controls (labeled as non-COVID) (c). d, Haplotypes of the three OAS1 variants used for analysis. e, Haplotype-specific imbalance in OAS1 expression contributed by rs1131454. All P values are for nonparametric, Wilcoxon matched-pairs two-sided signed-rank tests.