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. 2022 Jul 14;54(8):1103–1116. doi: 10.1038/s41588-022-01113-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, RNA-seq plots showing splicing patterns of OAS1 exons in representative samples from nasal epithelial cells uninfected (Mock) and rhinovirus (RV)-infected with strains A or C (RVA or RVC). OAS1 exon 3 shows alternative splicing at both 5’ acceptor and 3’ donor splice sites, resulting in four splicing junctions: two canonical junctions (CJ) and two alternative junctions (AJ) producing long and short versions of exon 3. Exon junctions AJ1 (major) and AJ2 (minor) account for approximately 25% and 5% of total RNA-seq reads, respectively. b–e, Splice quantitative trait locus (sQTL) analysis of AJ1 and AJ2 with rs1131454 in nasal epithelial cells uninfected (Mock) or infected with RVA or RVC (b,c) and in PBMCs from COVID-19 patients and healthy controls (labeled as non-COVID) (d,e). For b–e, P values are for linear regressions, adjusting for sex and age. All graphs show individual data points with means and 95% confidence intervals (CIs).