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. 2022 Jul 20;54(7):999–1010. doi: 10.1038/s12276-022-00809-w

Fig. 6. PBK facilitates olaparib resistance in vivo.

Fig. 6

a Photos of subcutaneous tumors. b The tumor volumes were computed. c The body weights of the mice. d Western blot was used to detect the protein levels of PARP1, caspase 3, XIAP, Bcl-XL, PBK, and β-actin in tumor tissues. e Representative photographs of IHC staining of Ki-67, cleaved caspase 3, XIAP, Bcl-XL, and PBK in xenograft tumors. f Quantification of the protein levels in d. g Quantification of the positive ratio of Ki-67, cleaved caspase 3, XIAP, Bcl-XL, and PBK in e. Scale bar: 100 µm. (Data are presented as the mean ± SEM, #p > 0.05, *p < 0.05, **p < 0.01, n = 6).