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. 2022 Aug 5;12:13484. doi: 10.1038/s41598-022-16754-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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WGCNA reveals that multiple circulating markers of NAFLD are co-regulated. (A) Network plot showing the 30 most central genes of M-Hep-8, as well as ALDOB, APOM, VTN, and AFM, four out of six recently identified NAFLD plasma proteome markers. Edge width is proportional to gene–gene co-expression and node size is proportional to gene ‘kIM’ centrality (Methods). (B) Violin plot showing the activity of M-Hep-1 in 12 cell clusters. (C) The biological function of module M-Hep-1, identified through gene set analysis using the Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and Reactome databases. Up to five of the top hits from each database shown. Only significant results were plotted (P < 0.05).