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. 2022 Aug 5;13(8):681. doi: 10.1038/s41419-022-05089-w

Fig. 1. Human osteoarthritic chondrocytes secrete sEVs containing high levels of Cx43.

Fig. 1

a Average size in nm of sEVs released by healthy (N CHs) and OA-derived chondrocytes, determined by nanoparticle tracking analysis (NTA). n = 4, Student’s t test. b Representative electron microscopy images of CD9-immunogold labelling from sEVs derived from OA chondrocytes. c Number of sEVs released by healthy and OA chondrocytes after 72 h, detected by NTA. n = 4, Student’s t test. d Representative images of the sEVs markers CD9 and CD81 in sEVs derived from OA chondrocytes. e sEVs derived from OA chondrocytes display increased levels of Cx43 when compared to sEVs derived from healthy chondrocytes. n = 3, Student’s t test. Data are expressed as mean ± S.E.M., *P < 0.05, ***P < 0.0001.