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. 2022 Aug 5;13(8):681. doi: 10.1038/s41419-022-05089-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a sEVs were isolated by ultracentrifugation and the protein content was analysed by mass spectrometry (TripleTOF 6600 System). Venn diagram showing the number of proteins quantified in both groups (sEVs-T/C in the left, sEVs-T/C-Cx43 in the right), and the heatmap of upregulated and downregulated proteins in the bottom. b Volcano plot (VolcaNoseR) illustrating the spectral count fold change and its significance in the common proteins shared by sEVs-T/C and sEVs-T/C-Cx43. Overrepresented proteins in sEVs-T/C-Cx43 are displayed as red dots, while blue dots represent proteins that are increased in the sEVs-T/C group. c Heatmaps representing the spectral count values and the −10log p-value of proteins involved in NF-kß transcription factor regulation, mitochondrial membrane permeabilization and organization, ROS response, immune response, apoptosis, mesenchymal cell differentiation and senescence. Black lines correspond to −10log p-value of sEVs-T/C and red lines to −10log p-value sEVs-T/C-Cx43.