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. 2022 Aug 5;13(8):681. doi: 10.1038/s41419-022-05089-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Venn diagram indicating the number of proteins identified in the proteomic analysis, and the heatmap of enriched pathways present in each group (n = 4). 114 proteins were exclusively found in sEVs isolated from OA-derived chondrocytes (left) and 161 were only identified in hCx43-sEVs (right). 499 common proteins (middle circle) were identified in both samples. Heatmaps represent significant function and pathways enriched in exclusive and common detected proteins, and analysed using STRING enrichment analysis (Gene Ontology and KEGG) based on quantitatively upregulated and downregulated proteins. b Volcano plot (VolcaNoseR) illustrating the correlation of fold change derived from the semiquantitative parameter spectral count and its significance, of the common proteins presents in both groups (sEVs from OA-derived chondrocytes-derived and sEVs derived from hCx43).