Fig. 5. Kataegis with respect to mutation signature.

a Relative frequencies of kataegic events are shown across tumor types. b For kataegic events in given tumor types, the relative frequencies of mutation signatures are shown. c–e Kataegic events with respect to mutation signatures are shown for three cancer genomes. In biliary adenocarcinomas (c), two kataegic events (arrows) are attributed to SBS16 mutations, suggesting that kataegis may arise with tumor-type-specific mutations. In one melanoma genome (d), three kataegic events (arrows) include a significantly enriched number of mutations arising from two mutational processes (SBS7 and SBS13). In one head and neck cancer genome (e), the selected example of kataegis (an arrow) includes mutations enriched for three mutation signatures (SBS7, SBS11 and SBS13).