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. 2022 Jul 26;54(7):1038–1048. doi: 10.1038/s12276-022-00811-2

Fig. 6. FNDC5/irisin ameliorates IVDD in rats in vivo.

Fig. 6

a Representative image of an X-ray of a rat tail disc at 0 and 4 weeks after disc puncture surgery. b Representative images of T2-weighted MRI of a rat-tail disc at 0 and 4 weeks after disc puncture surgery. c The disc height index of a rat-tail disc at 0 and 4 weeks after disc puncture surgery (N = 6). d Respective Pfirrmann grade scores at 0 and 4 weeks after disc puncture surgery (N = 6). e Representative HE staining and SO staining of discs from three experimental groups at 4 weeks (bar: 800 μm). f The histological grades evaluated at 4 weeks postsurgery in the three groups (N = 6). All data are shown as the mean ± SD. *p < 0.05, **p < 0.01.