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. 2022 Aug 5;13:4567. doi: 10.1038/s41467-022-32349-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — 1 PDA, Co-MOF, and ADT were synthesized by a one-pot method and modified with macrophage membranes to form PCoA@M. 2 PCoA@M became enriched in the tumour microenvironment through integrin targeting. 3 PCoA@M enhanced PTT by inhibiting HSPs, degrading under acidic conditions to release drugs, reducing NADH generation, and achieving PTT-gas synergistic starvation therapy. 4 PCoA@M inhibited tumour growth and metastasis.