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. 2022 Aug 5;13:4567. doi: 10.1038/s41467-022-32349-2

Fig. 4. Therapeutic effects of the probes at the cellular level.

Fig. 4

a Cumulative release of Co2+ at different times and pH values. Data are presented as the means ± s.d. (n = 3 independent samples). b Absorption (Abs) spectra of ADT release at different times. c CCK-8 cytotoxicity assessment of 4T1 cells incubated with different concentrations of H2S. Data are presented as the means ± s.d. (n = 6 independent samples). d Confocal images of 4T1 cells after incubation with PCoA@M + WSP-1 for different lengths of time. Scale bar: 50 μm. e, f EdU proliferation of 4T1 cells coincubated with different concentrations of H2S, PBS and PCoA@M. Scale bar: 50 μm. g Confocal images of 4T1 cells after incubation with Dil-labelled PCoA@M for different lengths of time. Scale bar: 50 μm. h Fluorescence images of calcein/PI-stained 4T1 and RAW 264.7 cells incubated with different probes under different conditions. Scale bar: 100 μm. i Flow cytometry analysis of 4T1 cell apoptosis under the different conditions mentioned above.