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. 2022 Jul 25;54(7):1024–1037. doi: 10.1038/s12276-022-00806-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b CircROCK1-E3/E4 expression levels after transfection of specific siRNAs were measured by an RT–qPCR assay. ^n.sp > 0.05 and ^**p < 0.01. c, d Expression levels of circROCK1-E3/E4 and ROCK1 mRNA were analyzed by an RT–qPCR assay. ^n.sp > 0.05 and ^**p < 0.01. e–h Changes in cell proliferation ability after various circROCK1-E3/E4 interventions were determined by a CCK8 assay. ^****p < 0.0001. i An EdU assay was performed to evaluate changes in cell proliferation ability after up- and downregulation of circROCK1-E3/E4. ^****p < 0.0001. j, k Cell motility ability changes after different circROCK1-E3/E4 interventions were determined by a transwell assay. ^****p < 0.0001. All data are presented as the mean ± SD from three independent experiments.