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. 2022 Jul 25;54(7):1024–1037. doi: 10.1038/s12276-022-00806-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Expression of PTEN after treatment with different miR-532-5p concentrations was determined by a western blot assay and an RT–qPCR assay. ^****p < 0.0001. c–f Cell proliferation ability changes in HOS and U2OS cells were determined by CCK8 and EdU assays, respectively. ^****p < 0.0001. g, h Cell migration and invasion ability changes in HOS and U2OS cells were measured by a transwell assay. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, and ^****p < 0.0001. i The targeted binding effect between miR-532-5p and PTEN was confirmed by a luciferase assay. The left panel shows the online prediction result by using TargetScan (http://www.targetscan.org/vert_72/), and the middle and right panels display the results of relative luminance changes. ^n.sp > 0.05 and ^*p < 0.05. All data are presented as the mean ± SD from three independent experiments.