Table 3.

Clinical phenotypes associated with IL-6 cQTLs.

rs number	Chr	Gene ID	Minor allele	IL6 levels in minor allele carriers	Phenotype	Minor allele carrier % Case	Minor allele carrier % Control	P value
rs139089467	6	CYP2AC1P	G	Lower	Unscheduled visit for asthma	20.6	15.8	0.03
chr2: 221028028:I	2	AC114765.1	CTATA	Lower	Oral steroids use	24.4	15.5	0.03
chr2: 22128028:I	2	AC114765.1	CTATA	Lower	GINA* step ≥ 2 at age 8	27.8	15.6	0.01

*GINA Global Initiative for Asthma; step 1 treatment is used for mild intermittent asthma. Step 2 treatment or above is required to treat more severe asthma.