Table 6.
Selected differentially expressed proteins in duck liver caused by pantothenic acid deficiency (PAD).
| UniProtKB ID | Protein name | Short name | Fold change1 | P-value |
|---|---|---|---|---|
| Glycogen synthesis and degradation | ||||
| U3J9R8 | Alpha-1,4 glucan phosphorylase | PYGL | −2.16 | 3.45E-06 |
| U3J383 | Phosphoglucomutase 1 | PGM1 | −2.30 | 1.06E-07 |
| R0LET4 | Glycogen synthase | GYS2 | −1.56 | 5.41E-04 |
| R0LKW3 | UTP--glucose-1-phosphate uridylyltransferase | UGP2 | −3.37 | 5.52E-11 |
| Glycolysis and gluconeogenesis | ||||
| R0LKR3 | Glucose-6-phosphate isomerase | GPI | −2.85 | 9.18E-06 |
| P13743 | L-Lactate dehydrogenase B chain | LDHB | −1.64 | 7.07E-06 |
| R0LQQ0 | Phosphoenolpyruvate carboxykinase 1 | PCK1 | −2.45 | 4.21E-05 |
| U3IEW2 | Pyruvate dehydrogenase E1 beta subunit | PDHB | −1.85 | 2.32E-04 |
| U3ILL1 | Pyruvate dehydrogenase E1 component subunit alpha | PDHA1 | −2.17 | 9.48E-05 |
| U3J1L1 | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | −3.24 | 4.64E-05 |
| U3IVG9 | Hexokinase domain containing 1 | HKDC1 | −3.62 | 2.53E-07 |
| U3I9L2 | phosphofructokinase, liver type | PFKL | −4.05 | 3.87E-07 |
| U3IR48 | Dihydrolipoyl dehydrogenase | DLD | −1.76 | 2.46E-05 |
| U3IHG8 | Fructose-bisphosphate aldolase | ALDOB | −1.67 | 8.52E-03 |
| U3ILF5 | Phosphoglycerate kinase | PGK1 | −2.23 | 5.75E-08 |
| U3I8D8 | Triosephosphate isomerase | TPI1 | −2.04 | 3.58E-04 |
| U3ICQ7 | Acetyltransferase component of pyruvate dehydrogenase complex | DLAT | −2.83 | 4.17E-03 |
| U3IW82 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex | PDHX | −2.23 | 3.71E-05 |
| U3J383 | Phosphoglucomutase 1 | PGM1 | −2.30 | 1.06E-07 |
| U3IM27 | Aldehyde dehydrogenase 2 family | ALDH2 | −1.50 | 6.32E-06 |
| U3IE74 | Lactate dehydrogenase A | LDHA | 3.33 | 5.50E-12 |
| U3IWS8 | Hexokinase 2 | HK2 | 2.56 | 2.22E-02 |
| PPAR signaling pathway | ||||
| A0A0H3U2H5 | Stearoyl-CoA desaturase1 | SCD1 | −3.31 | 4.65E-05 |
| R0LQQ0 | Phosphoenolpyruvate carboxykinase 1 | PCK1 | −2.45 | 4.21E-05 |
| U3I7T9 | Acyl-CoA synthetase family member 2 | ACSF2 | −1.55 | 1.07E-04 |
| U3I8S1 | Acyl-CoA synthetase bubblegum family member 2 | ACSBG2 | −5.91 | 7.92E-07 |
| U3IDQ1 | Acyl-coenzyme A oxidase | ACOX2 | −2.05 | 1.06E-06 |
| U3IIW2 | Fatty acid desaturase 2 | FADS2 | −3.32 | 2.90E-04 |
| U3IKU2 | Sterol carrier protein 2 | SCP2 | −2.51 | 9.84E-07 |
| U3IL38 | Malic enzyme 1 | ME1 | −4.04 | 5.86E-14 |
| U3INH3 | Sorbin and SH3 domain containing 2 | SORBS2 | −1.58 | 2.74E-02 |
| U3J4C8 | Fatty acid binding protein 7 | FABP7 | −2.56 | 6.74E-03 |
| Fatty acid oxidation | ||||
| U3J8S7 | Carnitine palmitoyltransferase 1A | CPT1A | 2.37 | 7.85E-05 |
| U3INM7 | Carnitine palmitoyltransferase 2 | CPT2 | 1.57 | 6.26E-03 |
| R0JG91 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | ACADS | 1.50 | 4.00E-03 |
| U3ITA9 | Acyl-CoA dehydrogenase medium chain | ACADM | 1.91 | 1.18E-02 |
| U3IAY7 | Acyl-CoA dehydrogenase long chain | ACADL | 1.88 | 4.37E-04 |
| U3J4J3 | Acetyl-CoA acetyltransferase 1 | ACAT1 | 3.50 | 8.53E-06 |
| U3IU30 | Acyl-CoA synthetase long chain family member 1 | ACSL1 | 1.91 | 1.29E-06 |
| U3J4Z9 | Acyl-CoA synthetase long chain family member 5 | ACSL5 | 3.13 | 3.36E-09 |
| U3I806 | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | HADHA | 2.00 | 1.49E-07 |
| U3I6S1 | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | HADHB | 2.23 | 7.26E-04 |
| U3J3G1 | Enoyl-CoA hydratase, short chain 1 | ECHS1 | 1.79 | 5.23E-03 |
| R0LHZ1 | 3-Ketoacyl-CoA thiolase, mitochondrial | ACAA2 | 1.78 | 1.44E-04 |
| U3IKG5 | Aldehyde dehydrogenase 9 family member A1 | ALDH9A1 | 1.51 | 5.09E-05 |
| U3IZY1 | Aldehyde dehydrogenase 7 family member A1 | ALDH7A1 | 1.68 | 4.77E-05 |
| U3IHS8 | Carnitine O-acetyltransferase | CRAT | 1.69 | 3.88E-03 |
| U3I624 | Glycerol kinase | GK | 1.60 | 9.37E-04 |
| Oxidative phosphorylation | ||||
| U3I998 | NADH:ubiquinone oxidoreductase core subunit S1 | NDUFS1 | 1.92 | 1.28E-05 |
| U3IVZ4 | NADH:ubiquinone oxidoreductase subunit B5 | NDUFB5 | 1.78 | 3.00E-02 |
| U3J3L1 | NADH:ubiquinone oxidoreductase core subunit V1 | NDUFV1 | 1.91 | 5.99E-03 |
| U3J9G0 | NDUFA4 mitochondrial complex associated | NDUFA4 | 1.99 | 1.90E-02 |
| U3IMS0 | NADH:ubiquinone oxidoreductase core subunit S3 | NDUFS3 | 1.69 | 2.49E-04 |
| R0JL39 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | UQCRFS1 | 1.64 | 4.12E-03 |
| U3I2D1 | Ubiquinol-cytochrome c reductase core protein 1 | UQCRC1 | 1.60 | 1.13E-04 |
| U3I342 | Ubiquinol-cytochrome c reductase core protein 2 | UQCRC2 | 1.93 | 1.57E-03 |
| A6ZJ02 | Cytochrome c oxidase subunit 2 | COX2 | 1.80 | 2.33E-02 |
| R0KK84 | ATP synthase subunit beta, mitochondrial | ATP5F1B | 1.74 | 1.46E-02 |
| R0LYJ7 | ATP synthase subunit d, mitochondrial | ATP5H | 1.82 | 7.41E-03 |
| U3IK89 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | ATP5C1 | 2.28 | 2.95E-04 |
| U3IVL6 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | ATP5A1 | 2.30 | 1.96E-03 |
| U3J9J8 | ATPase H+ transporting V1 subunit B2 | ATP6V1B2 | 1.71 | 1.95E-03 |
| U3IXX4 | Solute carrier family 25 member 5 | SLC25A5 | 4.27 | 1.97E-02 |
| TCA cycle | ||||
| R0J775 | Aconitase 1 (Fragment) | ACO1 | 1.69 | 1.43E-04 |
| R0L7Q0 | Fumarate hydratase (Fragment) | FH | 2.57 | 3.79E-04 |
| U3J597 | Isocitrate dehydrogenase | IDH1 | 3.80 | 2.72E-13 |
| U3IA60 | Malate dehydrogenase 2 | MDH2 | 3.95 | 2.45E-06 |
TCA = tricarboxylic acid.
1
Fold change is expressed as the ratio of the pantothenic acid-deficient (PAD) to the control (CON) group. For downregulated proteins, the fold change was transformed to the corresponding negative value.