Table 7.
Liver metabolites in ducks significantly affected by pantothenic acid deficiency (PAD).
| No. | Name | rt(s) | m/z | VIP | Metabolite | Fold change1 | P-value |
|---|---|---|---|---|---|---|---|
| 1 | M522T869 | 869 | 522.20 | 6.64 | Maltotriose | −19.89 | 2.14E-03 |
| 2 | M846T989 | 989 | 846.31 | 1.22 | Maltopentaose | −11.07 | 2.86E-03 |
| 3 | M360T752 | 752 | 360.15 | 3.30 | Cellobiose | −10.37 | 1.66E-03 |
| 4 | M325T753 | 753 | 325.11 | 2.68 | 3alpha-Mannobiose | −8.89 | 1.63E-03 |
| 5 | M269T405 | 405 | 269.09 | 3.10 | Inosine | −8.84 | 2.66E-06 |
| 6 | M383T72 | 72 | 383.33 | 1.80 | 25-hydroxyvitamin D3 | −4.76 | 8.61E-07 |
| 7 | M468T357 | 357 | 468.31 | 3.18 | LysoPC(14:0) | −3.48 | 3.31E-04 |
| 8 | M216T754 | 754 | 216.06 | 5.63 | sn-Glycerol 3-phosphoethanolamine | −3.47 | 2.17E-07 |
| 9 | M385T59 | 59 | 385.35 | 1.94 | Desmosterol | −3.28 | 1.91E-06 |
| 10 | M284T870 | 870 | 284.05 | 1.01 | N-Acetyl-D-Glucosamine 6-Phosphate | −3.20 | 8.57E-08 |
| 11 | M489T857 | 857 | 489.11 | 1.05 | Cytidine 5′-diphosphocholine (CDP-choline) | −3.11 | 3.39E-02 |
| 12 | M744T962 | 962 | 744.08 | 1.48 | Nicotinamide adenine dinucleotide phosphate | −3.09 | 3.46E-09 |
| 13 | M326T60 | 60 | 326.30 | 1.81 | N-Oleoylethanolamine | −2.95 | 8.28E-04 |
| 14 | M302T868 | 868 | 302.06 | 1.14 | N-Acetylglucosamine 1-phosphate | −2.93 | 7.21E-05 |
| 15 | M420T61 | 61 | 420.38 | 1.65 | 22beta-Hydroxycholesterol | −2.57 | 6.72E-04 |
| 16 | M113T298_2 | 298 | 113.03 | 5.62 | Uracil | −2.44 | 9.55E-07 |
| 17 | M613T964 | 964 | 613.16 | 4.44 | Glutathione disulfide | −2.37 | 1.92E-03 |
| 18 | M295T888 | 888 | 295.15 | 1.58 | Glycyl-Arginine | −2.35 | 1.12E-02 |
| 19 | M809T130 | 130 | 808.58 | 6.17 | PC(18:1(9Z)/18:1(9Z)) | −2.32 | 3.68E-02 |
| 20 | M262T298 | 298 | 262.10 | 4.01 | Uridine | −2.31 | 1.36E-04 |
| 21 | M779T108 | 108 | 778.54 | 1.72 | PC(16:0/16:0) | −2.30 | 3.42E-02 |
| 22 | M249T809 | 809 | 249.11 | 1.40 | Threoninyl-Glutamate | −2.29 | 8.45E-03 |
| 23 | M142T879 | 879 | 142.03 | 1.36 | O-Phosphoethanolamine | −2.27 | 1.14E-04 |
| 24 | M112T273 | 273 | 112.09 | 1.20 | Histamine | −2.13 | 4.09E-03 |
| 25 | M517T237 | 237 | 517.33 | 9.06 | Taurodeoxycholic acid | −2.06 | 4.75E-02 |
| 26 | M338T56_2 | 56 | 338.34 | 1.92 | Erucamide | −1.93 | 2.21E-03 |
| 27 | M118T665 | 665 | 118.06 | 4.86 | Guanidoacetic acid | −1.88 | 8.09E-06 |
| 28 | M121T209 | 209 | 121.05 | 1.05 | Purine | −1.88 | 2.16E-02 |
| 29 | M335T885 | 885 | 335.06 | 1.41 | Beta-nicotinamide D-ribonucleotide | −1.83 | 3.57E-02 |
| 30 | M339T82 | 82 | 339.25 | 1.50 | Cis-(6,9,12)-linolenic acid | −1.77 | 1.43E-02 |
| 31 | M337T888 | 888 | 337.17 | 1.26 | Arginyl-Tyrosine | −1.76 | 1.46E-02 |
| 32 | M664T841 | 841 | 664.12 | 1.56 | Nicotinamide adenine dinucleotide (NAD) | −1.75 | 7.93E-05 |
| 33 | M123T196 | 196 | 123.05 | 2.87 | Nicotinamide | −1.66 | 6.11E-03 |
| 34 | M235T834 | 834 | 235.09 | 1.29 | Glutamyl-Serine | −1.61 | 8.77E-04 |
| 35 | M500T288 | 288 | 500.30 | 2.78 | Tauroursodeoxycholic acid | −1.55 | 2.42E-02 |
| 36 | M522T341 | 341 | 522.35 | 5.17 | LysoPC(18:1(9Z)) | −1.53 | 2.84E-02 |
| 37 | M156T716_2 | 716 | 156.08 | 4.44 | L-Histidine | −1.47 | 3.06E-04 |
| 38 | M321T80 | 80 | 321.24 | 1.13 | 20-Hydroxyeicosatetraenoic acid | −1.47 | 3.10E-02 |
| 39 | M147T998 | 998 | 147.11 | 3.12 | L-Pipecolic acid | −1.35 | 2.57E-04 |
| 40 | M322T70 | 70 | 322.27 | 3.32 | Arachidonic acid (peroxide free) | −1.29 | 1.29E-02 |
| 41 | M222T490 | 490 | 222.10 | 1.36 | N-Acetyl-D-glucosamine | −1.26 | 2.41E-02 |
| 42 | M165T560_2 | 560 | 165.05 | 1.90 | Trans-2-hydroxycinnamic acid | −1.21 | 1.39E-03 |
| 43 | M136T560 | 560 | 136.07 | 1.45 | Dopamine | −1.21 | 7.62E-04 |
| 44 | M203T754 | 754 | 203.05 | 1.10 | Myo-inositol | −1.20 | 7.02E-04 |
| 45 | M182T560_2 | 560 | 182.08 | 2.43 | L-Tyrosine | −1.15 | 2.13E-02 |
| 46 | M120T502 | 502 | 120.08 | 1.12 | Tyramine | −1.14 | 1.09E-02 |
| 47 | M70T586 | 586 | 70.06 | 1.61 | Diethanolamine | 1.14 | 1.45E-02 |
| 48 | M116T586 | 586 | 116.07 | 4.47 | D-Proline | 1.16 | 1.99E-03 |
| 49 | M90T655 | 655 | 90.05 | 1.96 | L-Alanine | 1.23 | 5.66E-04 |
| 50 | M377T398 | 398 | 377.14 | 1.44 | Riboflavin | 1.33 | 6.44E-03 |
| 51 | M134T776 | 776 | 134.04 | 4.31 | L-Aspartate | 1.49 | 1.29E-04 |
| 52 | M291T907 | 907 | 291.13 | 1.10 | Argininosuccinic acid | 1.53 | 8.50E-03 |
| 53 | M204T194_1 | 194 | 204.09 | 1.22 | N-Acetylmannosamine | 1.55 | 2.07E-02 |
| 54 | M126T557_3 | 557 | 126.02 | 10.39 | Taurine | 1.62 | 8.20E-08 |
| 55 | M159T337 | 337 | 159.05 | 1.05 | Allantoin | 1.69 | 2.37E-02 |
| 56 | M162T746 | 746 | 162.11 | 1.67 | L-Carnitine | 1.74 | 1.27E-04 |
| 57 | M811T133 | 133 | 810.60 | 3.07 | 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC) | 1.80 | 4.10E-02 |
| 58 | M168T191 | 191 | 168.06 | 2.26 | Pyridoxal (vitamin B6) | 1.85 | 1.79E-02 |
| 59 | M285T411 | 411 | 285.08 | 1.86 | Xanthosine | 1.89 | 1.16E-05 |
| 60 | M243T775 | 775 | 243.03 | 1.09 | Alpha-D-glucose 1-phosphate | 1.90 | 8.96E-06 |
| 61 | M136T294 | 294 | 136.06 | 1.87 | Adenine | 2.09 | 5.87E-04 |
| 62 | M229T205 | 205 | 229.08 | 2.19 | 2′-Deoxyuridine | 2.12 | 2.56E-03 |
| 63 | M160T732 | 732 | 160.13 | 2.59 | Cyclohexylamine | 2.15 | 1.13E-05 |
| 64 | M169T629_2 | 629 | 169.04 | 5.10 | Uric acid | 2.22 | 1.20E-06 |
| 65 | M146T676_2 | 676 | 146.09 | 4.94 | 4-Guanidinobutyric acid | 2.23 | 3.15E-05 |
| 66 | M568T318 | 318 | 568.34 | 1.81 | 1-Stearoyl-sn-glycerol 3-phosphocholine | 2.35 | 7.61E-03 |
| 67 | M298T145 | 145 | 298.10 | 3.15 | S-Methyl-5′-thioadenosine | 2.43 | 4.88E-06 |
| 68 | M204T576 | 576 | 204.12 | 3.38 | Acetylcarnitine | 2.44 | 1.19E-03 |
| 69 | M209T478 | 478 | 209.09 | 2.67 | L-Kynurenine | 2.45 | 5.20E-05 |
| 70 | M114T78 | 78 | 114.09 | 2.38 | Triethanolamine | 2.45 | 5.53E-08 |
| 71 | M192T478_1 | 478 | 192.06 | 2.23 | 5-Hydroxyindoleacetate | 2.49 | 2.13E-05 |
| 72 | M127T179 | 179 | 127.05 | 3.26 | Thymine | 2.55 | 2.65E-03 |
| 73 | M130T581 | 581 | 130.09 | 3.52 | D-Pipecolic acid | 2.66 | 7.27E-04 |
| 74 | M112T385 | 385 | 112.05 | 1.25 | Cytosine | 2.66 | 2.18E-04 |
| 75 | M127T615 | 615 | 127.05 | 3.42 | Imidazoleacetic acid | 2.68 | 6.25E-07 |
| 76 | M243T180 | 180 | 243.10 | 4.04 | Thymidine | 2.74 | 3.38E-03 |
| 77 | M160T784 | 784 | 160.06 | 1.89 | DL-2-Aminoadipic acid | 2.75 | 3.51E-02 |
| 78 | M184T68 | 68 | 184.06 | 1.61 | 4-Pyridoxic acid | 2.95 | 1.88E-02 |
| 79 | M130T119 | 119 | 130.09 | 3.91 | 2-Pyrrolidineacetic acid | 2.99 | 2.70E-04 |
| 80 | M133T778 | 778 | 133.01 | 3.60 | L-Malic acid | 3.21 | 3.40E-02 |
| 81 | M428T286 | 286 | 428.37 | 2.50 | Stearoylcarnitine | 3.41 | 1.93E-05 |
| 82 | M241T772 | 772 | 241.01 | 1.08 | Alpha-D-galactose 1-phosphate | 3.48 | 8.04E-03 |
| 83 | M170T681 | 681 | 170.09 | 2.90 | 1-Methylhistidine | 3.78 | 1.60E-05 |
| 84 | M151T377 | 377 | 151.04 | 2.36 | p-Hydroxyphenylacetic acid | 4.09 | 5.36E-03 |
| 85 | M241T212_2 | 212 | 241.09 | 1.33 | Acadesine (Drug) | 4.10 | 5.67E-03 |
| 86 | M61T181 | 181 | 61.04 | 1.96 | Urea | 4.56 | 1.84E-05 |
| 87 | M209T552 | 552 | 209.07 | 1.33 | D-Ribose | 4.77 | 1.30E-02 |
| 88 | M211T637 | 637 | 211.08 | 1.72 | Ribitol | 4.79 | 9.37E-03 |
| 89 | M277T873 | 873 | 277.14 | 3.03 | L-Saccharopine | 4.96 | 1.35E-04 |
| 90 | M400T294 | 294 | 400.34 | 3.20 | L-Palmitoylcarnitine | 5.05 | 3.55E-06 |
| 91 | M131T745 | 745 | 131.04 | 1.22 | Glutaric acid | 5.09 | 6.56E-03 |
| 92 | M129T106_2 | 106 | 129.06 | 12.59 | ketoisocaproic acid | 5.20 | 2.75E-03 |
| 93 | M181T200_2 | 200 | 181.07 | 1.66 | Methoxyacetic acid | 5.94 | 8.58E-05 |
| 94 | M254T364 | 364 | 254.09 | 1.74 | Succinate | 6.20 | 8.40E-06 |
| 95 | M163T74_2 | 74 | 163.04 | 9.12 | Phenylpyruvate | 6.21 | 1.69E-03 |
| 96 | M114T312 | 312 | 114.06 | 3.54 | Creatinine | 6.22 | 1.84E-04 |
| 97 | M455T385 | 385 | 455.19 | 1.04 | Deoxycytidine | 8.59 | 1.86E-03 |
| 98 | M136T173 | 173 | 136.04 | 1.32 | Anthranilic acid (Vitamin L1) | 12.42 | 5.45E-04 |
| 99 | M132T659_2 | 659 | 132.08 | 12.68 | Creatine | 13.01 | 5.81E-06 |
m/z = mass-to-charge ratio; VIP = variable importance in the projection.
1
Fold change is expressed as the ratio of the PAD to the control (CON) group. For downregulated metabolites, the fold change was transformed to the corresponding negative value.