Table 3.
Comparative analysis of the prognostic significance of proteins (A) and genes (B) differentially expressed in P and NP low-risk ccRCC, as detected in this multi-omics evaluation and in unselected ccRCC, based on data from The Cancer Genome Atlas as evaluated in https://www.proteinatlas.org and https://xenabrowser.net, respectively.
| All ccRCC protein overexpression | p | FC P/NP | Low risk ccRCC protein overexpression | |
|---|---|---|---|---|
| (A) | ||||
| TTR | Unfavorable | 0.0082 | − 5.09 | Favorable |
| DTD1 | Unfavorable | 0.0077 | − 3.52 | Favorable |
| HMGB1 | Irrelevant | 0.15 | − 3.15 | Favorable |
| TINAGL1 | Favorable | 0.00041 | − 3.01 | Favorable |
| C8G | Unfavorable | 1.20E−07 | − 2.97 | Favorable |
| SERPING1 | Unfavorable | 0.006 | − 2.85 | Favorable |
| VCAN | Unfavorable | 0.00052 | − 2.66 | Favorable |
| APOA1 | Unfavorable | 1.70E−08 | − 2.61 | Favorable |
| PLG | Favorable | 6.40E−09 | − 2.54 | Favorable |
| A1BG | Unfavorable | 0.0014 | − 2.53 | Favorable |
| HBA1 | Favorable | 0.0067 | − 2.52 | Favorable |
| RPL15 | na | na | − 2.42 | Favorable |
| SEPT-2 | Unfavorable | 0.0096 | − 2.4 | Favorable |
| DSP | Favorable | 0.00012 | 4.77 | Unfavorable |
| ITIH1 | Unfavorable | 0.00077 | 3.44 | Unfavorable |
| DEFA3 | Irrelevant | 0.18 | 3.25 | Unfavorable |
| PTMS | Unfavorable | 0.014 | 2.86 | Unfavorable |
| NPC2 | Favorable | 0.0031 | 2.57 | Unfavorable |
| ATP6V1G1 | Favorable | 3.4E−06 | 2.49 | Unfavorable |
| PTMA | Unfavorable | 0.0016 | 2.44 | Unfavorable |
| All ccRCC gene overexpression | p | FC P/NP | Low risk ccRCC gene overexpression | |
|---|---|---|---|---|
| (B) | ||||
| SLC12A1 | Irrelevant | 0.343 | − 14.31 | Favorable |
| AC146944.1 | Irrelevant | 0.054 | − 11.82 | Favorable |
| IGHA2 | Irrelevant | 0.142 | − 9.18 | Favorable |
| IGLL5 | Unfavorable | 0.0012 | − 9.13 | Favorable |
| SLC9A4 | Irrelevant | 0.33 | − 8.84 | Favorable |
| SV2B | Irrelevant | 0.342 | 14.84 | Unfavorable |
| FAM86B2 | Irrelevant | 0.52 | 12.92 | Unfavorable |
| NPIPB9 | Unfavorable | 0.0048 | 12.16 | Unfavorable |
| ANKRD20A7P | Irrelevant | 0.219 | 11.74 | Unfavorable |
| LBP | Unfavorable | 0.0048 | 10.86 | Unfavorable |
| ADGRB1 | Unfavorable | 0.000026 | 9.56 | Unfavorable |
| ASAH2 | Irrelevant | 0.292 | 9.4 | Unfavorable |
| PLK4 | Unfavorable | 0.0086 | 9.25 | Unfavorable |
| STAG3 | Irrelevant | 0.595 | 9.21 | Unfavorable |
| ZNF321P | na | na | 9,09 | Unfavorable |
| AC135048.4 | na | na | 8.84 | Unfavorable |
| NPIPB1P | Irrelevant | 0.06 | 8.81 | Unfavorable |
| SYS1 | Irrelevant | 0.831 | 8.46 | Unfavorable |
| RMRP | na | na | 8.18 | Unfavorable |
| SNORD116-18 | na | na | 10.3 | Unfavorable |
The favorable and unfavorable designation relates to how the expression of a molecule was associated with a improved of diminished prognosis.