Table 1.
Summary of BIO 300 Oral Powder single dose PK parameters in NHPs.
| Dose | Animals | Tmax (h) | Cmax (ng/ml) | AUC0-48 (ng h/ml) | AUC0-inf (ng h/ml) | T1/2 (h) |
|---|---|---|---|---|---|---|
| 100 mg/kg | All | 1.0 ± 0.71 | 662.8 ± 329.1 | 2481 ± 822.2 | 2505 ± 832.2 | 1.69 ± 0.17 |
| Males | 0.75 ± 0.35 | 633.5 ± 326.0 | 2201 ± 1304 | 2214 ± 1315 | 1.56 ± 0.01 | |
| Females | 1.25 ± 1.1 | 692.0 ± 463.9 | 2761 ± 120.9 | 2796 ± 94.2 | 1.83 ± 0.11 | |
| 200 mg/kg | All | 1.13 ± 0.63 | 2867 ± 3632 | 7645 ± 3937 | 7649 ± 3938 | 1.78 ± 0.27 |
| Males | 0.75 ± 0.35 | 4504 ± 5369 | 7026 ± 6672 | 7030 ± 6673 | 1.73 ± 0.46 | |
| Females | 1.5 ± 0.71 | 1230 ± 183.8 | 8268 ± 676.7 | 8268 ± 678.2 | 1.84 ± 0.01 |
Results mean ± SD.