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. 2022 Aug 5;12:13508. doi: 10.1038/s41598-022-17752-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gold nanoparticle uptake in in vivo mouse xenograft model. (a) Total gold uptake in the tumour after 8, 24, 48, and 72 h for tumours treated with gold or treated with gold and docetaxel. DTX refers to docetaxel treated samples and CTL refers to control samples with no docetaxel. (b,c) Total gold nanoparticles per gram of tissue for plasma, tumour, kidney, liver, and spleen after treatment (b) without docetaxel and (c) with docetaxel, after 8, 24, 38, and 72 h. Error bars are the 95% confidence interval from four independent mice. ns indicates no significance, * indicates 0.01 < p < 0.05. (d,e) Darkfield images of 5 µm sections of tumour tissue 8, 24, 48, and 72 h after (d) gold nanoparticle treatment and after (e) concurrent gold nanoparticle and docetaxel treatment. Inset is hyper spectral spectrum of gold nanoparticles and cells. Scale bar is 40 µm.