Figure 1.

Classification of the tumor immune microenvironment on the basis of PD-L1 expression and CD8⁺ TIL density. (A) Tumor immune microenvironment for 133 patients with SCLC classified according to cutoffs for PD-L1 expression (combined positive score) and CD8⁺ TIL density of 1% and the median (85/mm²), respectively. Tumors with a PD-L1^positive and CD8⁺ TIL^high immune microenvironment were designated as inflamed, and all other tumors as noninflamed. (B) Kaplan-Meier curves for progression-free survival of patients with inflamed tumors (n = 7) or noninflamed tumors (n = 56) in the ICI combo-cohort. (C) Kaplan-Meier curves for progression-free survival of patients with inflamed tumors (n = 13) or noninflamed tumors (n = 57) in the chemo-cohort. CI, confidence interval; HR, hazard ratio; NR, not reached; PD-L1, programmed death-ligand 1; TIL, tumor-infiltrating lymphocyte.