Fig. 10.

Heatmap of significantly enriched Reactome Pathways in DS: Comparisons are shown on the X axis with Reactome Pathways on the Y axis. When performing tests for enrichment, pathways were restricted to include only those with 2 or more genes. Note that for the purposes of display, only Reactome Pathways with an enrichment p-value less than 0.05, were included. Furthermore, only the top 50 pathways are displayed. Color is assigned based on the -log10(enrichment p-value), with lighter colors implying less significant enrichment. Hierarchical clustering was applied to pathways (rows). The most significant pathways were clustered according to Euclidean distance using the complete linkage method. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)