Fig. 7.

DS cells exhibit a markedly enhanced glycolytic and impaired Krebs cycle fluxomic profile compared to healthy control cells; effect of AOAA. Isotopologues present in the distal steps of glycolysis and the Krebs cycle, as well as steps of serine biosynthesis are shown in n = 8 human euploid control fibroblasts and n = 8 DS fibroblasts, as summarized in Table 1, with/without AOAA treatment (3 μM). **p ≤ 0.01 indicates significant differences between DSC untreated vs. CC untreated; ^#p ≤ 0.05, ^##p ≤ 0.01 indicates significant differences between DSC + AOAA vs. DSC untreated.