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. 2022 Jul 22;13:921728. doi: 10.3389/fimmu.2022.921728

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Copyright © 2022 Yap, Ueda, Kanemitsu, Takeda, Fukumitsu, Fukuda, Uemura, Tajiri, Ohkubo, Maeno, Ito, Oguri, Ugawa and Niimi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL6 release after PolyIC–WD–TNF in (A) MRC-5 cells and (B) HF-19 cells and the effect of TLR3 and NF-κB inhibitors on its release. Preexposure to Poly (I:C) significantly increased TNFα-induced IL6 release in both MRC-5 (P < 0.005) and HF-19 (P < 0.005) cells. Both inhibitors significantly decreased IL6 release in MRC-5 cells (P < 0.01 and P < 0.0001 for TLR3i and Bay-11-7082, respectively) and HF-19 cells (P < 0.01 and P < 0.05 for TLR3i and Bay-11-7082, respectively). N = 6. Values with * were defined significant when compared to (-)-WD-(-) while *above bar were significant between two variables.