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. 2022 Jul 22;13:925772. doi: 10.3389/fphys.2022.925772

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Copyright © 2022 Charest-Pekeski, Cho, Aujla, Sun, Floh, McVey, Sheta, Estrada, Crawford-Lean, Foreman, Mroczek, Belik, Saini, Lim, Moir, Lee, Quinn, Darby, Seed, Morrison and Haller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Layout of the pumped AP circuit. Fetal pigs (n = 13) were delivered via caesarean section, cannulated via the UA’s and UV, and maintained using a pumped AP circuit. Fetal pigs (n = 12) were also maintained using the same circuit design but without a centrifugal pump. Blood passed through the UAs and the centrifugal pump before entering the inflow port of the oxygenator. Oxygenated blood then passes through the oxygenator outflow port before returning to the heart via the UV. Sweep gas supplied the oxygenator with medical air and oxygen and the Biobag was filled with warmed LR solution to maintain fetal normothermia.