Table 1.

Summary of papers by pathology category

Category	Number of publications	Number of CTE cases (n)	Protein (antibodies) investigated
Tau	31	Adams et al. [2], n = 86 Arena et al. [6], n = 22 Arena et al. [7], n = 14 Armstrong et al. [10], n = 11 Armstrong et al. [11], n = 8  Armstrong et al. [12], n = 11 Armstrong et al. [13], n = 4 Cherry et al. [26], n = 48 Cherry et al. [27], n = 45 Cherry et al. [23], n = 41 Combs and Kanaan [28] n = 5 Dale et al. 30], n = 11 Geddes et al.  [36], n = 4 Goldstein et al. [37], n = 8 Hof et al. [40], n = 3 Hsu et al. [44], n = 14 Kanaan et al. [46], n = 9 Kaufman et al. 48], n = 27 Kondo et al. [50], n = 16 Lucke-Wold et al. [54], n = 2 Mann et al. [55], n = 4 McKee et al. [59], n = 9 McKee et al. [60], n = 68 McKenzie et al. [61], n = 5 Moszczynski et al. [66], n = 5 Puvenna et al. [74], n = 6 Roberts et al.  [75], n = 8 Roberts et al. [76] n = 20 Seo et al. [78], n = 6 Standring et al. [80], n = 251 Walt et al. [88], n = 9	Bielschowski stain [30, 59, 76] Phospho-neurofilament medium (BF10 [30, 75]) Tau 210 kDa (RT97 [75]) Pan-tau (aa210-230) (TAU-5 [74]) Conformation dependent p-tau (Alz-50 [61], GT7 [7], GT38 [6, 7]) Tau C-terminus (A0024 [36]) PAD exposed p-tau (TNT1 [46], TNT2 [28]) oligomeric p-tau (TOC1 [46], T22 [66]) tau cleaved D421 (TauC3 [46]) Tau N-terminus (Tau13 [7, 28]) 3R p-tau [7, 23] 4R p-tau [7, 23] PPP3CA [78] Phospho-tau pS199 [78] Phospho-tau pS202/pT205 (AT8 [10–13, 23, 26, 27, 44, 48, 59, 60, 74, 78], CP-13 [6, 7, 74]) Phospho-tau pS212/pT214 (AT100 [7]) Phospho-tau pS262 [7] Phospho-tau pS396/pS404 (PHF-1 [7, 59]) Phospho-tau pS396 [78] Phospho-tau pS422 [46] Phospho-tau pT175 [66] Phospho-tau pT231 [66]
Beta-amyloid	6	Armstrong [8], n = 6 Armstrong [9], n = 6 Hof et al. [40], n = 3 Roberts et al. [76], n = 20 Standring et al. [80], n = 251 Stein et al. [84], n = 114	Beta-Amyloid 1–42 (4G8 [40, 80], 4D12 [76], AB5078P [8–10, 12, 84]) Beta-Amyloid 1–40 (AB5074P [84]) Thioflavin S stain [40]
TDP-43	4	Anderson et al. [5], n = 18 King et al. [49], n = 3 McKee et al. [59], n = 9 McKee et al. [60] n = 68	Pan TDP-43 [49, 59, 60] Phospho-TDP-43 [5, 49]
Lewy body	4	Adams et al. [2], n = 86 Kaufman et al. [48], n = 27 Mann et al. [55], n = 4 McKee et al. [60], n = 68	Alpha-synuclein [2, 48, 55, 60]
Astrogliosis	4	Chancellor et al. [21], n = 8 Cherry et al. [26], n = 48 Cherry et al. [27], n = 45 Hsu et al. [44], n = 14	GFAP [21, 26, 44] CD44 [21] NQO1 [27]
Microgliosis	3	Cherry et al. [25] n = 46 Cherry et al. [26], n = 48 Goldstein et al. [37], n = 8	HLA-DR [37] Iba1 [25, 26] CD68 [26] TMEM119 [25]
Axonopathy	5	Bi et al. [15], n = 5 Chancellor et al. [21], n = 8 Goldstein et al. [37], n = 8 McKee et al. [60], n = 68 Warling et al. [89], n = 11	Phospho-neurofilament heavy [37, 60] βIII tubulin [15] Myelin-associated glycoprotein [15] Olig2 [21] Golgi stain [89]
Vascular dysfunction	3	Adams and Bruton [1], n = 18 Buée et al. [19], n = 2 Standring et al. [80], n = 251	Beta-amyloid [80] Perivascular iron deposition [1] Heparan sulfate proteoglycan [19]
Cell stress	3	Anderson et al. n = 18 Dale et al. [30] n = 11 Lucke-Wold et al. [54], n = 2	XBP1 [54] phospho-eIF2a [54] ATF6 [54] CHOP [54] Ubiquitin [30] NUP62 [5]