Table 2.
The characteristics of therapeutic targets
| Gene Symbol | Protein names | UniPort ID | Degree | Betweenness | Closeness |
|---|---|---|---|---|---|
| TP53 | Cellular tumor antigen p53 | P04637 | 26 | 119.80086 | 0.744681 |
| CASP3 | Caspase-3 | P42574 | 24 | 89.589681 | 0.729167 |
| MYC | Myc proto-oncogene protein | P01106 | 24 | 41.276849 | 0.714286 |
| ESR1 | Estrogen receptor | P03372 | 24 | 102.85391 | 0.729167 |
| JUN | Transcription factor AP-1 | P05412 | 24 | 53.369635 | 0.714286 |
| PTGS2 | Prostaglandin G/H synthase 2 | P35354 | 23 | 72.477952 | 0.729167 |
| PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | 21 | 158.33969 | 0.714286 |
| CASP8 | Caspase-8 | Q14790 | 19 | 12.393883 | 0.648148 |
| AR | Androgen receptor | P10275 | 18 | 12.240176 | 0.636364 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | P38936 | 18 | 13.525691 | 0.636364 |
| CASP9 | Caspase-9 | P55211 | 17 | 8.2618119 | 0.625 |
| IL1B | Interleukin-1 beta | P01584 | 17 | 52.104864 | 0.648148 |
| CCNB1 | G2/mitotic-specific cyclin-B1 | P14635 | 15 | 4.9289352 | 0.59322 |
| CDK1 | Cyclin-dependent kinase 1 | P06493 | 14 | 4.7454907 | 0.57377 |
| PGR | Progesterone receptor | P06401 | 14 | 3.452711 | 0.583333 |
| KDR | Vascular endothelial growth factor receptor 2 | P35968 | 14 | 1.6679282 | 0.59322 |
| BAX | Apoptosis regulator BAX | Q07812 | 13 | 1.8816711 | 0.57377 |
| NOS2 | Nitric oxide synthase, inducible | P35228 | 12 | 11.292795 | 0.57377 |
| PRKCA | Protein kinase C alpha type | P17252 | 12 | 15.963106 | 0.59322 |
| BCL2 | Apoptosis regulator Bcl-2 | P10415 | 10 | 0.9061896 | 0.538462 |
| PRKCD | Protein kinase C delta type | Q05655 | 10 | 8.6580533 | 0.564516 |
| ESR2 | Estrogen receptor beta | Q92731 | 10 | 1.1598973 | 0.555556 |
| NCOA2 | Nuclear receptor coactivator 2 | Q15596 | 9 | 6.10359 | 0.546875 |
| ADRB2 | Beta-2 adrenergic receptor | P07550 | 9 | 98.01746 | 0.538462 |
| AKR1B1 | Aldo-keto reductase family 1 member B1 | P15121 | 9 | 22.285304 | 0.57377 |
| FASN | Fatty acid synthase | P49327 | 7 | 5.0822475 | 0.530303 |
| PCNA | Proliferating cell nuclear antigen | P12004 | 6 | 0 | 0.486111 |
| PTGS1 | Prostaglandin G/H synthase 1 | P23219 | 6 | 0.2352941 | 0.514706 |
| SLC6A4 | Sodium-dependent serotonin transporter | P31645 | 5 | 43.590673 | 0.492958 |
| PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | 5 | 1.7936508 | 0.466667 |
| DPP4 | Dipeptidyl peptidase 4 | P27487 | 4 | 68 | 0.486111 |
| CHRM2 | Muscarinic acetylcholine receptor M2 | P08172 | 2 | 0 | 0.368421 |
| DRD1 | D(1A) dopamine receptor | P21728 | 2 | 0 | 0.368421 |
| PON1 | Serum paraoxonase/arylesterase 1 | P27169 | 1 | 0 | 0.421687 |
| DPEP1 | Dipeptidase 1 | P16444 | 1 | 0 | 0.330189 |
| PRSS1 | Trypsin-1 | P07477 | 1 | 0 | 0.432099 |
| F7 | Coagulation factor VII | P08709 | 0 | 0 | 0 |