Table 6.
Multivariate logistic regression models including potential determinants associated with mortality
| Characteristic | OR | 95% CI | p | |
|---|---|---|---|---|
| Baseline modela | Female | 1.02 | 0.50—2.06 | 0.958 |
| Age, y | 1.03 | 1.01—1.06 | 0.017 | |
| Problem localizationb | 2.88 | 1.44—5.77 | 0.003 | |
| Comorbidities, n | 0.99 | 0.79—1.25 | 0.958 | |
| LRINEC | 1.00 | 0.89—1.13 | 0.992 | |
| Model 1 | Debridements, n | 0.83 | 0.76—0.91 | < 0.001 |
| Model 2 | VAC therapy | 0.17 | 0.08—0.36 | < 0.001 |
| Model 3 | Mesh graft | 0.06 | 0.03—0.16 | < 0.001 |
| Model 4 | Flap | 0.09 | 0.01—0.73 | 0.024 |
| Model 5 | Amputation | 2.09 | 0.98—4.46 | 0.058 |
| Model 6 | HBOT, yes | 1.06 | 0.49—2.30 | 0.884 |
| HBOT no, ineligible | 8.59 | 1.90—38.86 | 0.005 | |
| Model 7 | Positive blood culture | 3.36 | 1.57—7.20 | 0.002 |
| Model 8 | Antibiotic groups, n | 0.97 | 0.74—1.26 | 0.800 |
| Model 9 | ICU treatment | 7.26 | 0.88—59.91 | 0.065 |
| Model 10 | Days in hospital | 0.94 | 0.93—0.96 | < 0.001 |
| Model 11 | Complications | 10.35 | 3.35—32.07 | < 0.001 |
| Model 12 | Infections | 0.72 | 0.36—1.41 | 0.337 |
| Model 13 | Sepsis/organ dysfunction | 19.58 | 8.06—48.20 | < 0.001 |
OR Odds ratio, CI confidence interval, FG Fournier`s gangrene, HBOT hyperbaric oxygen therapy, ICU intensive care unit, LRINEC Laboratory Risk Indicator for NECrotizing fasciitis, n number, NF necrotizing fasciitis, VAC vacuum-assisted closure, y years
aThe baseline model contained mortality as dependent variable and sex, age, problem localization, LRINEC and number of comorbidities as independent variables. In models 1–13, one additional parameter per model was integrated as independent variable. Age, number of comorbidities, number of debridements, number of antibiotic groups and days in hospital were included as continuous variables. The reference group for female was male. The reference category for "HBOT, yes" and "HBOT no, ineligible" contained patients who did not obtain HBOT because it was not indicated. Reference groups for all other parameters consisted of patients without the respective characteristic
bThe category "problem localizations" comprised patients with NF or FG in the retroperitoneal area, head/neck region and/or in multiple localizations. Significant findings are highlighted in bold