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A patient with infantile systemic hyalinosis at 8 months old (a–g) and 4 years old (h–o). (a) Papular skin rash on hands. (b and c) Hyperpigmentation over prominent of lateral malleolus. (d–g) Periosteal reaction in the humerus, ulna, femur and tibia. (h and i) Pearly papules around neck. (j and k) Cutaneous nodules and hyperpigmentation at chest and back. (l) Gingival hypertrophy. (m) Perianal plaques. (n and o) Joint contractures of foots.
