Figure 5.

Normal mode analysis (NMA) modeling of docked vaccine-TLR4 complexes. Modeling the deformability of the main chain, the hinge is an area with high deformability (A). B-factor values were calculated from NMA to quantify the uncertainty of each atom (B). Eigenvalues of adjacent complexes represent the energy required to deform the structure (C). Covariance matrix between pairs of residues (red: correlated, white: uncorrelated, blue: anti-correlated) (D). Elastic network model assuming bonding between atoms and springs; the darker the grey, the stiffer the spring (E).