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. 2022 Aug 2;16:2463–2478. doi: 10.2147/DDDT.S370574

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© 2022 Alzyoud et al.

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(A) The M^pro enzyme in the dimer form with co-crystallized ligands, (B) x1086 (PDB:5RGQ51) and (C) x1187 (PDB:5RFA51) at the dimer interface indicates opportunities for allosteric modulation. For clarity, superimposition on the dimer form of M^pro (PDB:7CAM79) was performed to demonstrate binding onto the dimerization site.