Table 1.

Gene Variants Directly or Indirectly Affecting Cognitive Function.

Gene	Associated Diseasea	SNP ID	hg19 Position	Allele	Derived Global AFb	Archaic Genotype
						Altai	Denisovan
AGT	Sodium retention	rs699	1:230845794	G	0.295	0/0	0/0
				A
BIN1	AD	rs7561528	2:127889637	A	0.8	0/0	0/0
				G
SGC2	Hypertension	rs1017448	2:224466344	T	0.879	0/0	0/0
				C
CAPN10	Type II Diabetes	rs2975760	2:241531163	C	0.882	1/1	1/1
				T
PPARG	Type II Diabetes	rs1801282	3:12393125	C	0.070	0/0	0/0
				G
CYP3A5	Sodium retention	rs776746	7:99270539	T	0.621	0/0	0/0
				C
ARID5B	AD	rs2588969	10:63611354	A	0.532	0/0	1/1
				C
SPON1	Dementia	rs2618516	11:14021639	C	0.341	0/0	0/0
				T
PICALM	AD	rs10792832	11:85867875	G	0.313	0/0	0/0
				A
		rs3851179	11:85868640	C	0.315	0/0	0/0
				T
APOE	LOAD	rs429358	19:45411941	C	0.849	0/0	0/0
				T
		rs7412	19:45412079	C	0.075	0/0	0/0
				T
CD33	LOAD	rs3865444	19:51727962	C	0.211	0/0	0/0
				A
PILRA	AD	rs1859788	7:99971834	G	0.341	−	−
				A
TCFLC2	Type II Diabetes	rs7903146	10:114758349	T	0.772	−	−
				C
CD33	LOAD	rs12459419	19:51728477	C	0.211	−	−
				T

Note.—Allele has the derived allele as the lower, bolded entry. Archaic genotypes are reported for SNPs passing all quality filters.

^aSee supplementary table 1, Supplementary Material online for details and the primary literature citations.

^bSee supplementary table 2, Supplementary Material online for the global population distribution.