Table 1.
Baseline Characteristics of Participants Stratified by Age and Gender
| Number | Total | 60–69 | 70–79 | ≥80 | P value |
|---|---|---|---|---|---|
| n=3814 | n=1715 | n=1490 | n=609 | ||
| Age,yr | 72.21 (72.01–72.43) | 66.51 (66.31–66.70) | 74.65 (74.35–74.94) | 82.93 (82.56–83.30) | <0.001 |
| TSH,mIU/L | 3.49 (3.42–3.56) | 3.19 (3.07–3.31) | 3.47 (3.33–3.61) | 3.97 (3.68–4.25) | <0.001 |
| ASCVD,n(%) | 830 (21.7) | 293 (17.1) | 371 (24.9) | 166 (27.3) | <0.001 |
| WC,cm | 86.75 (86.46–87.06) | 85.51 (85.03–85.98) | 87.37 (86.81–87.93) | 88.67 (87.64–89.69) | <0.001 |
| BMI,kg/m2 | 24.60 (24.50–24.71) | 24.63 (24.45–24.81) | 24.82 (24.61–25.03) | 24.44 (24.05–24.83) | 0.044 |
| SBP,mmHg | 138.92 (138.38–139.48) | 136.54 (135.65–137.43) | 140.72 (139.64–141.80) | 143.22 (141.56–144.88) | <0.001 |
| DBP,mmHg | 81.802 (81.52–82.09) | 82.28 (81.82–82.74) | 81.36 (80.81–81.92) | 80.93 (80.01–81.85) | <0.001 |
| FG,mmol/L | 5.76 (5.70–5.82) | 5.65 (5.56–5.74) | 5.78 (5.56–6.00) | 6.28 (6.23–6.34) | 0.156 |
| HbA1c,% | 6.35 (6.32–6.39) | 6.28 (6.23–6.34) | 6.34 (6.28–6.41) | 6.32 (6.21–6.44) | 0.045 |
| TC, mmol/L | 4.98 (4.95–5.01) | 5.01 (4.96–5.06) | 5.00 (4.94–5.06) | 4.99 (4.89–5.09) | 0.487 |
| TG, mmol/L | 1.61 (1.58–1.65) | 1.67 (1.61–1.73) | 1.63 (1.57–1.69) | 1.47 (1.39–1.55) | <0.001 |
| HDL-C, mmol/L | 1.46 (1.45–1.47) | 1.45 (1.43–1.47) | 1.44 (1.42–1.47) | 1.51 (1.47–1.56) | <0.001 |
| LDL-C, mmol/L | 3.31 (3.28–3.33) | 3.33 (3.29–3.38) | 3.35 (3.30–3.41) | 3.33 (3.24–3.42) | 0.571 |
| Cr,μmol/L | 76.90 (76.11–77.70) | 72.26 (71.39–73.13) | 77.21 (75.93–78.48) | 81.59 (79.35–83.83) | <0.001 |
| UA,μmol/L | 328.66 (325.91–331.42) | 320.08 (315.71–324.46) | 330.07 (324.93–335.21) | 342.43 (332.67–352.18) | <0.001 |
| Hcy,μmol/L | 15.96 (15.66–16.25) | 14.14 (13.74–14.54) | 16.26 (15.72–16.79) | 19.17 (17.93–20.42) | <0.001 |
| Hgb,g/L | 138.3 (137.8–138.7) | 140.5 (139.7–141.2) | 137.2 (136.3–138.1) | 134.0 (132.4–135.5) | <0.001 |
| hsCRP,mg/L | 1.58 (1.52–1.63) | 1.44 (1.36–1.53) | 1.75 (1.64–1.86) | 1.75 (1.57–1.93) | 0.001 |
| Men,n | 1682 | 768 | 667 | 247 | |
| TSH,mIU/L | 3.14 (3.04–3.24) | 2.85 (2.71–2.98) | 3.14 (3.00–3.29) | 4.05 (3.71–4.38) | <0.001 |
| ASCVD,n(%) | 375 | 133 (17.3) | 163 (24.4) | 77(31.2) | <0.001 |
| Women,n | 2132 | 947 | 823 | 362 | |
| TSH,mIU/L | 3.76 (3.67–3.86) | 3.52 (3.38–3.67) | 3.88 (3.73–4.04) | 4.11 (3.89–4.33) | <0.001 |
| ASCVD,n(%) | 457 | 160 (16.9) | 208 (25.3) | 89 (24.6) | <0.001 |
Notes: Data are presented as mean (95% CI) for continuous variables and n (%) for categorical variables. P value comparing differences between three groups with ANOVA test.
Abbreviations: TSH, thyroid stimulating hormone; ASCVD, arteriosclerotic cardiovascular disease, includes history of MI, coronary or other arterial revascularization, stroke, or peripheral arterial disease; WC, waist circumference; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FG, fasting glucose; HbA1c, glycosylated hemoglobin; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; TG, triglyceride; Cr, Creatinine; UA, Uric acid; Hcy, serum total homocysteine; Hgb, hemoglobin; hsCRP, high-sensitivity C-reactive protein.