Table 7.
Effect of aqueous root extract of Euclea divinorum on body weight, temperature and packed cell volume of P. berghei infected mice in the repository test.
| Groups | Body weight | Rectal temperature | Packed cell volume | ||||||
|---|---|---|---|---|---|---|---|---|---|
| D0 | D3 | (%) change | D0 | D3 | (%) change | D0 | D3 | (%) change | |
| CON | 24.96 ± 0.83 | 23.31 ± 1.20 | −6.61 | 35.6 ± 0.41 | 34.67 ± 0.43 | −2.61 | 54.45 ± 2.04 | 52.87 ± 1.98 | −2.9 |
| CQ25 mg/kg | 24.34 ± 1.12 | 24.8 ± 1.21 | 1.89a3 | 35.7 ± 0.40 | 35.87 ± 0.25 | 0.47a2 | 55.84 ± 3.35 | 56.45 ± 3.10 | 1.09a2 |
| 100 mg/kg | 24.20 ± 0.88 | 23.30 ± 0.76 | −3.72b1 | 36.0 ± 0.35 | 35.42 ± 0.19 | −1.16 | 55.14 ± 0.86 | 54.03 ± 1.10 | −2.01b2 |
| 200 mg/kg | 29.37 ± 1.07 | 29.35 ± 1.27 | −0.07a2 | 36.03 ± 0.29 | 35.67 ± 0.28 | −1.00 | 51.69 ± 2.10 | 51.28 ± 2.01 | −0.79 |
| 400 mg/kg | 27.17 ± 1.13 | 27.32 ± 1.12 | 0.56a2 | 36.17 ± 0.39 | 36.13 ± 0.47 | −0.11a1 | 54.24 ± 1.02 | 54.13 ± 0.87 | −0.20a1 |
Data are expressed as mean ± SEM; n = 6; a, compared to negative control; b, to CQ25 mg/kg; c, to 100 mg/kg; d, to 200 mg/kg; e, to 400 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; CON, control; CQ, chloroquine.