Table 4.

Binding energy scoring of the synthesized ligands (MSJ 1-10) with targeted proteins.

Ligands	Binding energies (Kcal/mol)
	Acetylcholinesterase	Butyrylcholinesterase	α-amylase	α-Glucosidase
	1EVE	4BDS	5U3A	5NN3
MSJ1	−6.5	−6.7	−7.1	−7.4
MSJ2	−8.7	−8.9	−8.2	−8.5
MSJ3	−6.9	−7.2	−7.4	−7.8
MSJ4	−7.5	−7.8	−7.1	−7.2
MSJ5	−6.9	−6.5	−6.5	−6.6
MSJ6	−7.1	−7.5	−7.4	−7.8
MSJ7	−7.4	−7.5	−7.4	−7.7
MSJ8	−6.9	−6.5	−6.4	−6.8
MSJ9	−6.6	−6.6	−6.7	−6.7
MSJ10	−9.5	−9.1	−8.2	−8.8
Galantamine	−9.9	−9.6	—	—
Acarbose	—	—	−9.1	−9.5