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. 2022 Jul 30;2022:8440422. doi: 10.1155/2022/8440422

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Copyright © 2022 Tingting Jin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Molecular mechanisms by which ANTXR1 regulates γ-globin expression via the Wnt/β-catenin signaling pathway. The interaction of ANTXR1 with LRP6 may inhibit the activity of the β-catenin destructive complex consisting of Axin, APC, and Gsk3 via Frizzled. β-Catenin is then free to translocate to the nucleus where it binds to the TCF/LEF transcription factors, thereby promoting the transcription of target gene c-Jun, which, in turn, activates the expression of SOX6, a repressor of γ-globin genes, thereby inhibiting the expression of γ-globin genes.