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The mechanism of ferroptosis induced by iron overload in osteoporosis. Ferroptosis induced by iron overload leads to an increase in mitochondrial membrane potential and the accumulation of lipid peroxide by affecting glutathione and fatty acid cycle. It further promotes the activation of osteoclasts and the apoptosis of osteoblasts, leading to the increase of bone resorption and the decrease in bone formation, resulting in osteoporosis and finally osteoporotic fracture.
