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. 2022 Jul 30;2022:3112388. doi: 10.1155/2022/3112388

Table 1.

Comparison of cell death in ferroptosis, autophagy, and apoptosis.

Comparison of characteristics of cell death in ferroptosis, autophagy, and apoptosis
Cell death types Ferroptosis Autophagy Apoptosis
Morphological characteristics Smaller mitochondria, decreased mitochondrial ridge Autolysosome Cells became round, chromatin is condensed and fragmented, and cytoplasm shrunk
Other features Iron ion aggregation, cell membrane rupture No obvious changes in the nucleus and membrane Cell shrinks, cytoplasm flows out, and membrane vacuoles
Detection index ROS, PTGS↑; NADPH↓ LC3-I→LC3II Caspase↑; intracellular Ca2+
Positive regulatory factor Erastin, RSL3, RAS, Sorafenib, p53 ATG family, Beclin1 P53, Bax, Bak, TGF-β, radiation, dexamethasone
Negative regulatory factor GPX4, FSP1, SLC7A11, Nrf2, ferrostatin-1, liproxstatin-1, DFO mTOR, 3-methyladenine, wortmannin, Spautin1 Bcl-2, Bcd-XL, Z-VAD-FMK, IL-4