Table 3.
Overview of inhibitors of ferroptosis.
| Target | Inhibitor | Mechanisms associated with ferroptosis |
|---|---|---|
| ROS and iron ions | Minocycline | Minocycline reduces iron overload after ICH and iron induced brain injury |
| Ferrostain-1 | Scavenge ROS, inhibit lipid peroxidation, and reduce unstable iron in cells | |
| Liproxstatin-1 | Scavenge ROS, inhibit lipid peroxidation, and activate the Nrf2 signaling pathway | |
| Curcumin | Chelate iron, reduce iron accumulation, and activate the Nrf2 signaling pathway | |
| Alpha tocopherol analogs | Remove ROS and inhibit lipid peroxidation | |
| Nitrogen oxides | Inhibit Fenton reaction and hydroxyl radical production | |
| GSH and GPX4 | Baicalein | Inhibit GSH depletion, GPX4 degradation, and lipid peroxidation and activate the Nrf2 signaling pathway |
| Gastrodin | Inhibit glutamate-induced iron death in HT-22 cells | |
| ACSL4 | Rezulin | Prevention of ferroptosis and lipid peroxidation in Pfa1 cells induced by RSL3 |
| 5-LOx | Zileuton | Protect ACSL4 overexpressed LNCaP and K562 cells from erastin-induced ferroptosis |
| TFR1 and FTH1 | HSPB1 | Inhibit ferroptosis induced by erastin |
| Lipid peroxidation | XJB-5-131 | Suppress lipid peroxidation |
| Iron | Deferoxamine | Deplete iron and prevent iron-dependent lipid peroxidation |