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An interplay of circMELK and miR-497-5p. circMELK and MELK mRNA after RNase R treatment (a) and after actinomycin D treatment (b), and their expression in nucleus and cytoplasm (c). Binding sites of circMELK and miR-497-5p (d) and verification of the binding relation (e)-(f). miR-497-5p expression in OA patients and in vitro cell model (g)-(h). miR-497-5p expression after regulation of circMELK (i). ∗P < 0.05.
