Figure 3.

Statistical power for the different combinations of methods and nuclear‐family designs at genome‐wide significance level ($5\times {10}^{-8}$). Results are based on simulated data on 1,000 families from one homogenous racial/ethnic group with 10,000 nonnull SNPs at MAF 10% at the casual SNP, and a common disease prevalence of 30%. Results for data simulated using the recessive inheritance model are not shown due to nearly zero power of these methods at the chosen parameter values. All offspring were affected, and all parents were unaffected. (a) Comparison of designs with the same number of families of different compositions. (b) Comparison of the combined analysis of 750 case–mother dyads and 250 case–parent trios against the scenarios when either all dyads or all trios are removed from analysis. GDT, generalized disequilibrium test; gTDT, genotypic TDT; MAF, minor allele frequency; SNP, single nucleotide polymorphism; TDT, transmission disequilibrium test