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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Br J Dermatol. 2022 Jun 2;187(2):223–233. doi: 10.1111/bjd.21060

Figure 4: Histological analysis demonstrates decreased inflammatory infiltration in hidradenitis suppurativa (HS) lesional and perilesional skin following treatment with brodalumab.

Figure 4:

A) Hematoxylin and Eosin (H&E) stain demonstrates a mild reduction in epidermal thickness in lesional skin. There is also comparable reduction of B) CD3+ infiltration, and C) CD11c+ infiltration in both perilesional and lesional skin. Scale bar = 100 μM. D) Quantification of total inflammatory infiltration across the patient cohort (n=10 patients). Dashed line represents infiltrate quantification of nonlesional skin at baseline. Error bars show standard error of mean (SEM), with two-way ANOVA analysis. Stars denote significance with * p ≤ 0.05 ** p ≤ 0.01 *** p ≤ 0.001.