Table 3:
Association between MUTYH carrier status and Incident Cancer and Colorectal Risks by Sex
| All Cancer | Colorectal Cancer | Extracolonic Cancer* |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Non- carrier |
MUTYH Carrier |
Non- carrier |
MUTYH
carrier |
Non- carrier |
MUTYH
carrier |
||||
| HR (95% CI) |
HR (95% CI) |
P | HR (95% CI) |
HR (95% CI) |
P | HR (95% CI) |
HR (95% CI) |
P | |
| Female | |||||||||
| Model 1a | 1 | 1.53 (0.90, 2.58) | 0.114 | 1 | 0.71 (0.10, 5.11) | 0.736 | 1 | 1.67 (0.97, 2.88) | 0.065 |
| Model 2b | 1 | 1.57 (0.93, 2.66) | 0.092 | 1 | 0.79 (0.11, 5.66) | 0.844 | 1.71 (0.99, 2.95) | 0.054 | |
| Model 3c | 1 | 1.47 (0.85, 2.54) | 0.170 | 1 | 0.81 (0.11, 5.79) | 0.831 | 1 | 1.58 (0.89, 2.80) | 0.115 |
| Model 4d | 1 | 1.45 (0.84, 2.51) | 0.187 | 1 | 0.81 (0.11, 5.82) | 0.113 | 1 | 1.55 (0.88, 2.75) | 0.130 |
| Male | |||||||||
| Model 1a | 1 | 1.66 (1.04, 2.66) | 0.035 | 1 | 3.50 (1.41, 8.66) | 0.007 | 1 | 1.41 (0.82, 2.43) | 0.216 |
| Model 2b | 1 | 1.68 (1.05, 2.68) | 0.032 | 1 | 3.54 (1.43, 8.79 | 0.006 | 1 | 1.41 (0.82, 2.45) | 0.209 |
| Model 3c | 1 | 1.67 (1.04, 2.68) | 0.035 | 1 | 3.53 (1.42, 8.78) | 0.007 | 1 | 1.41 (0.81, 2.44) | 0.220 |
| Model 4d | 1 | 1.66 (1.03, 2.68) | 0.038 | 1 | 3.55 (1.43, 8.79) | 0.006 | 1 | 1.40 (0.81, 2.44) | 0.229 |
*:
All cancers excluding colorectal cancer and non-melanoma skin cancers.
a
Univariate Cox regression analysis.
b
Multivariable Cox regression analysis adjusting for age, smoking status, and alcohol use
c
Multivariable Cox regression analysis adjusting for age, smoking status, alcohol use, baseline BMI, and randomization to aspirin.
d
Multivariable Cox regression analysis adjusting for age, smoking status, alcohol use, baseline BMI, randomization to aspirin, history of cancer (all cancer and extracolonic risk only), history of CRC (CRC risk only), and history of colon polyps (CRC risk only).