Table 3.
Enrichment patterns of the Allen brain expression candidate gene sets
| Components | Gene sets | P(95%) | P(75%) | EXP#genes | OBS#genes | P(FDR-BH) |
|---|---|---|---|---|---|---|
| Common | MFG | 0.11 | 3.0e-3 | 241 | 275 | 1.80e-2 |
| SCG | 0.29 | 0.09 | 239 | 254 | 0.18 | |
| LOC | 0.23 | 0.26 | 242 | 249 | 0.31 | |
| BG | 0.49 | 0.08 | 240 | 256 | 0.18 | |
| Updating-specific | MFG | 0.40 | 0.29 | 241 | 247 | 0.32 |
| SCG | 0.55 | 0.19 | 239 | 249 | 0.27 | |
| LOC | 0.46 | 0.19 | 241 | 251 | 0.27 | |
| BG | 0.63 | 0.53 | 240 | 238 | 0.53 | |
| Shifting-specific | MFG | 0.27 | 0.02 | 143 | 164 | 0.08 |
| SCG | 0.22 | 2.3e-3 | 139 | 166 | 1.8e-2 | |
| LOC | 0.50 | 0.06 | 149 | 165 | 0.18 | |
| BG | 0.96 | 0.20 | 139 | 147 | 0.27 |
MFG = the set of genes that showed enhanced expression in the middle frontal gyrus; SCG = the set of genes that showed enhanced expression in the paracingulate (subcallosal cingulate) gyrus; LOC = the set of genes that showed enhanced expression in the occipital gyrus, superior division; BG = the set of genes that showed enhanced expression in the basal ganglia. P(95%): nominal gene-set enrichment P value for a candidate gene set (95% cutoff); P(75%): nominal gene-set enrichment P value for a candidate gene set (75% cutoff); EXP#genes (75%): expected number of genes that were above 75% cutoff; OBS#genes (75%): observed number of genes that were above 75% cutoff. Correction for multiple comparisons was performed with the FDR-BH. One-sided test.