Figure 4.

Synergy estimates of Gemcitabine and Paclitaxel combination in organoid ex vivo pharmacotyping of case 010 presented in 2D plot (A) and 3D surface plot (B). The red areas reflect synergy of the axis concentrations by ZIP synergy score. Despite the red peak, the result shows practically no synergistic effect of the selected drug combination. Synergy tensor cubes showing the viability-based inhibition after ex vivo pharmacotyping by the combinations of the three drugs (5-FU, Irinotecan and Oxaliplatin) for a more sensitive culture 001 (C) and for a more resistant culture 041 (D). ZIP synergy scores (E-F) after combination pharmacotyping of 5-FU, Irinotecan and Oxaliplatin. Negative ZIP scores throughout reflect the lack of synergy of the drugs in the combination.