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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: J Thorac Oncol. 2022 Jun 9;17(8):1014–1031. doi: 10.1016/j.jtho.2022.05.014

Figure 1: LSD1 expression is highly overexpressed in small cell lung cancer and inversely correlated with the expression of genes encoding the antigen presentation pathway.

Figure 1:

(A) KDM1A mRNA expression was profiled in 29 unique cancer types; data from Cancer Cell Line Encyclopedia (CCLE) (Broad, 2019) (Downloaded from cBioPortal). (B) KDM1A expression was queried in primary tumors previously analyzed in the SCLC-Atlas51, consisting of LUAD (n=24) and SCLC (n=21) clinical samples. (C) KDM1A expression was profiled at the single-cell level from the SCLC-Atlas dataset51, consisting of 54,313 SCLC transcriptomes, 3341 LUAD transcriptomes and matched normal tissues. (D) Pearson’s correlations between LSD1 (KDM1A) expression and HLA-A, HLA-B, HLA-C, B2M, TAP1, TAP2, LMP-2 (PSMB8), LMP-7 (PSMB9) from SCLC-Global (downloaded from CellMiner). Values were calculated as RNAseq RPKM (log2(value+1)).