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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Eur J Cell Biol. 2022 Apr 22;101(3):151228. doi: 10.1016/j.ejcb.2022.151228

Figure 2.

Figure 2.

Localization and functions of APC in cells. (a) APC clusters at microtubule tips initiate branched actin assembly at the cell leading edge for membrane protrusion; (b) APC clusters assembled in the vicinity of focal adhesions nucleate linear actin filaments to facilitate focal adhesion turnover by as yet unknown mechanism; (c) APC can localize to cell-cell junctions, but its roles at this location remain unclear. APC can accumulate at microtubule tips through interaction with EB family +TIPs or be delivered by kinesin family motors.