Figure 5.

All three of the functional electrophysiological alterations that might produce SA are associated with patient-reported pain. Neurons from DRGs associated with dermatomal pain had depolarized RMP (A) (unpaired t test), hyperpolarized AP threshold (B) (Mann-Whitney U test), and increased DSF amplitude (C) (Mann-Whitney test) compared with other neurons. RMP and AP threshold measurements were not corrected for the liquid junction potential, so actual values might be up to 15 mV more negative (see Methods).