Figure 2: Normoxic and hypoxic graded exercise tests in humans with HAH and healthy controls.

(A, B) Box plots depicting the percent change in VȮ₂peak and PPO from normoxia to hypoxia. (C, E) Heart rate and $\stackrel{.}{\mathrm{V}}{\mathrm{O}}_2$ during the normoxic graded exercise test. (D, F) Heart rate and $\stackrel{.}{\mathrm{V}}{\mathrm{O}}_2$ during the hypoxic graded exercise test. Abbreviations: HAH; high affinity hemoglobin, $\stackrel{.}{\mathrm{V}}{\mathrm{O}}_2$; peak oxygen uptake; PPO; peak power output, $\stackrel{.}{\mathrm{V}}{\mathrm{O}}_2\text{peak}$; oxygen uptake, bpm; beats per minute, L/min, liters per minute. Heart rate and $\stackrel{.}{\mathrm{V}}{\mathrm{O}}_2$ data are presented as mean ± SD.